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Pfizer COVID Vaccine Trial Shows Alarming Evidence of Pathogenic Priming in Older Adults
The Vaccines and Related Biological Products Advisory Committee Briefing Document on the Pfizer-BioNTech COVID-19 vaccine contains disturbing indications that might be a safety signal on pathogenic priming, especially in older adults.
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In the development of vaccines against coronaviruses like SARS-COV-1 and MERS in the early 2000’s, researchers found evidence of a serious problem. Teams of U.S. and foreign scientists vaccinated animals with the four most promising vaccines. At first, the experiment seemed successful as all the animals developed a robust antibody response to coronavirus. However, when the scientists exposed the vaccinated animals to the wild virus, the results were horrifying. Vaccinated animals suffered hyper-immune responses including inflammation throughout their bodies, especially in their lungs.
This issue is well known. Early in the COVID-19 scenario, Dr. Peter Hotez, of Baylor College of Medicine, testified before Congress about the dangers of accelerating coronavirus vaccine development, saying “(The) unique safety problem of coronavirus vaccines” was discovered 50 years ago while developing the Respiratory Syncytial Virus (RSV) vaccine.”
He went to register that this “‘paradoxical immune enhancement phenomenon’ means vaccinated people may still develop the disease, get sicker and die.”
Researchers had seen this same “enhanced immune response” during human testing of the failed RSV vaccine tests in the 1950s. The vaccines not only failed to prevent infection; 80% of the children infected required hospitalization, and two children challenged with the RSV died (see Openshaw, 2005). In April of 2020, Hotez told CNN, “If there is immune enhancement in animals, that’s a showstopper.”
There’s been a serious terminology problem with this issue. The problem, of course, is not “immune enhancement,” which sounds like something helpful to the immune system. In fact, it is quite the opposite.
The problem is, in reality “disease enhancement”; in fact, that is what it was called in the original RSV study.
Disease enhancement now appears to be caused by initial exposure to a pathogen’s proteins, or parts of proteins, which primes the body to autoimmunity. That is “pathogenic priming.” In COVID-19, every protein in the SARS-CoV-2 has at least one epitope that matches human proteins someplace in the human body. About one-third of the epitopes in SARS-CoV-2 virus that match human proteins match immune system proteins.
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